Table 5.
Adiposity Measurea | Person-Years | No. of CHD Events | HRb | 95% CI | HRc | 95% CI | HRde | 95% CI |
Body mass index | ||||||||
Quintile 1 | 8,712 | 152 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,308 | 168 | 1.11 | 0.89, 1.39 | 1.08 | 0.87, 1.35 | 1.03 | 0.82, 1.28 |
Quintile 3 | 9,350 | 156 | 1.02 | 0.81, 1.27 | 1.00 | 0.80, 1.25 | 0.90 | 0.72, 1.14 |
Quintile 4 | 9,449 | 167 | 1.11 | 0.89, 1.39 | 1.06 | 0.85, 1.32 | 0.92 | 0.73, 1.16 |
Quintile 5 | 8,872 | 202 | 1.53 | 1.23, 1.89 | 1.42 | 1.14, 1.77 | 1.11 | 0.88, 1.40 |
Ptrend | 0.001 | 0.006 | 0.66 | |||||
Body mass index at age 50 years | ||||||||
Quintile 1 | 9,453 | 137 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,411 | 165 | 1.23 | 0.98, 1.54 | 1.23 | 0.98, 1.55 | 1.19 | 0.95, 1.49 |
Quintile 3 | 9,231 | 159 | 1.26 | 1.00, 1.58 | 1.25 | 1.00, 1.58 | 1.21 | 0.96, 1.52 |
Quintile 4 | 9,121 | 182 | 1.41 | 1.13, 1.76 | 1.40 | 1.12, 1.75 | 1.24 | 0.99, 1.55 |
Quintile 5 | 8,475 | 202 | 1.80 | 1.45, 2.24 | 1.71 | 1.37, 2.14 | 1.40 | 1.11, 1.76 |
Ptrend | <0.001 | <0.001 | 0.009 | |||||
Fat mass | ||||||||
Quintile 1 | 8,537 | 165 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,324 | 172 | 1.07 | 0.86, 1.32 | 1.06 | 0.86, 1.32 | 1.00 | 0.80, 1.24 |
Quintile 3 | 9,541 | 161 | 0.96 | 0.77, 1.19 | 0.92 | 0.74, 1.15 | 0.82 | 0.66, 1.03 |
Quintile 4 | 9,413 | 147 | 0.97 | 0.77, 1.21 | 0.94 | 0.75, 1.18 | 0.79 | 0.62, 1.00 |
Quintile 5 | 8,875 | 200 | 1.49 | 1.21, 1.85 | 1.40 | 1.13, 1.74 | 1.13 | 0.89, 1.42 |
Ptrend | 0.003 | 0.02 | 0.88 | |||||
Fat-free mass | ||||||||
Quintile 1 | 8,564 | 172 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,090 | 153 | 0.88 | 0.71, 1.10 | 0.91 | 0.73, 1.14 | 0.91 | 0.73, 1.13 |
Quintile 3 | 9,353 | 177 | 1.01 | 0.82, 1.24 | 1.04 | 0.85, 1.29 | 1.02 | 0.83, 1.27 |
Quintile 4 | 9,286 | 188 | 1.14 | 0.93, 1.41 | 1.17 | 0.95, 1.44 | 1.07 | 0.87, 1.33 |
Quintile 5 | 9,397 | 155 | 0.92 | 0.74, 1.15 | 0.93 | 0.74, 1.15 | 0.83 | 0.66, 1.04 |
Ptrend | 0.69 | 0.68 | 0.48 | |||||
Waist circumference | ||||||||
Quintile 1 | 9,555 | 163 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,056 | 142 | 0.96 | 0.77, 1.20 | 0.95 | 0.76, 1.20 | 0.90 | 0.72, 1.13 |
Quintile 3 | 9,275 | 166 | 1.10 | 0.89, 1.36 | 1.08 | 0.87, 1.34 | 0.99 | 0.79, 1.24 |
Quintile 4 | 9,166 | 178 | 1.19 | 0.96, 1.47 | 1.16 | 0.94, 1.44 | 1.05 | 0.84, 1.31 |
Quintile 5 | 8,638 | 196 | 1.49 | 1.21, 1.84 | 1.39 | 1.12, 1.72 | 1.11 | 0.88, 1.39 |
Ptrend | <0.001 | 0.001 | 0.17 | |||||
Hip circumference | ||||||||
Quintile 1 | 9,656 | 180 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 8,893 | 163 | 0.99 | 0.80, 1.23 | 0.97 | 0.79, 1.20 | 0.92 | 0.74, 1.14 |
Quintile 3 | 9,121 | 162 | 1.05 | 0.85, 1.31 | 1.06 | 0.85, 1.31 | 0.99 | 0.79, 1.22 |
Quintile 4 | 9,549 | 154 | 0.96 | 0.78, 1.19 | 0.94 | 0.75, 1.17 | 0.84 | 0.68, 1.06 |
Quintile 5 | 8,471 | 186 | 1.35 | 1.10, 1.66 | 1.26 | 1.02, 1.55 | 1.02 | 0.82, 1.27 |
Ptrend | 0.02 | 0.08 | 0.89 | |||||
Waist/hip ratio | ||||||||
Quintile 1 | 9,719 | 139 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,378 | 162 | 1.21 | 0.96, 1.51 | 1.19 | 0.95, 1.50 | 1.12 | 0.89, 1.41 |
Quintile 3 | 8,904 | 174 | 1.34 | 1.07, 1.67 | 1.31 | 1.04, 1.63 | 1.16 | 0.92, 1.46 |
Quintile 4 | 9,106 | 175 | 1.36 | 1.09, 1.70 | 1.33 | 1.06, 1.66 | 1.19 | 0.94, 1.49 |
Quintile 5 | 8,584 | 195 | 1.64 | 1.32, 2.04 | 1.56 | 1.25, 1.94 | 1.36 | 1.08, 1.71 |
Ptrend | <0.001 | <0.001 | 0.010 | |||||
Waist/height ratio | ||||||||
Quintile 1 | 9,358 | 144 | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent |
Quintile 2 | 9,560 | 144 | 0.97 | 0.77, 1.22 | 0.95 | 0.75, 1.20 | 0.88 | 0.70, 1.12 |
Quintile 3 | 9,137 | 179 | 1.27 | 1.02, 1.59 | 1.25 | 1.00, 1.55 | 1.16 | 0.93, 1.45 |
Quintile 4 | 9,143 | 172 | 1.22 | 0.98, 1.53 | 1.16 | 0.93, 1.45 | 1.01 | 0.80, 1.28 |
Quintile 5 | 8,483 | 206 | 1.63 | 1.32, 2.02 | 1.51 | 1.22, 1.88 | 1.21 | 0.96, 1.52 |
Ptrend | <0.001 | <0.001 | 0.040 |
Abbreviations: CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio.
Adjusted for age, sex, and race (black, nonblack).
Adjusted for age, sex, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), serum creatinine, and hormone replacement therapy (women).
Adjusted for age, sex, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), serum creatinine, hormone replacement therapy (women), systolic blood pressure, antihypertensive medication use, diabetes, prediabetes, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, use of aspirin, and high-sensitivity C-reactive protein.
Models with and without inclusion of high-sensitivity C-reactive protein yielded similar effect estimates across measures and are therefore not presented separately.