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. 2010 Dec 1;173(1):10–25. doi: 10.1093/aje/kwq311

Table 5.

Relations of Quintiles of Body Size and Composition Measures With Incident Coronary Heart Disease in the Cardiovascular Health Study Sample, United States, 1989–2007

Adiposity Measurea Person-Years No. of CHD Events HRb 95% CI HRc 95% CI HRde 95% CI
Body mass index
    Quintile 1 8,712 152 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,308 168 1.11 0.89, 1.39 1.08 0.87, 1.35 1.03 0.82, 1.28
    Quintile 3 9,350 156 1.02 0.81, 1.27 1.00 0.80, 1.25 0.90 0.72, 1.14
    Quintile 4 9,449 167 1.11 0.89, 1.39 1.06 0.85, 1.32 0.92 0.73, 1.16
    Quintile 5 8,872 202 1.53 1.23, 1.89 1.42 1.14, 1.77 1.11 0.88, 1.40
        Ptrend 0.001 0.006 0.66
Body mass index at age 50 years
    Quintile 1 9,453 137 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,411 165 1.23 0.98, 1.54 1.23 0.98, 1.55 1.19 0.95, 1.49
    Quintile 3 9,231 159 1.26 1.00, 1.58 1.25 1.00, 1.58 1.21 0.96, 1.52
    Quintile 4 9,121 182 1.41 1.13, 1.76 1.40 1.12, 1.75 1.24 0.99, 1.55
    Quintile 5 8,475 202 1.80 1.45, 2.24 1.71 1.37, 2.14 1.40 1.11, 1.76
        Ptrend <0.001 <0.001 0.009
Fat mass
    Quintile 1 8,537 165 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,324 172 1.07 0.86, 1.32 1.06 0.86, 1.32 1.00 0.80, 1.24
    Quintile 3 9,541 161 0.96 0.77, 1.19 0.92 0.74, 1.15 0.82 0.66, 1.03
    Quintile 4 9,413 147 0.97 0.77, 1.21 0.94 0.75, 1.18 0.79 0.62, 1.00
    Quintile 5 8,875 200 1.49 1.21, 1.85 1.40 1.13, 1.74 1.13 0.89, 1.42
        Ptrend 0.003 0.02 0.88
Fat-free mass
    Quintile 1 8,564 172 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,090 153 0.88 0.71, 1.10 0.91 0.73, 1.14 0.91 0.73, 1.13
    Quintile 3 9,353 177 1.01 0.82, 1.24 1.04 0.85, 1.29 1.02 0.83, 1.27
    Quintile 4 9,286 188 1.14 0.93, 1.41 1.17 0.95, 1.44 1.07 0.87, 1.33
    Quintile 5 9,397 155 0.92 0.74, 1.15 0.93 0.74, 1.15 0.83 0.66, 1.04
        Ptrend 0.69 0.68 0.48
Waist circumference
    Quintile 1 9,555 163 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,056 142 0.96 0.77, 1.20 0.95 0.76, 1.20 0.90 0.72, 1.13
    Quintile 3 9,275 166 1.10 0.89, 1.36 1.08 0.87, 1.34 0.99 0.79, 1.24
    Quintile 4 9,166 178 1.19 0.96, 1.47 1.16 0.94, 1.44 1.05 0.84, 1.31
    Quintile 5 8,638 196 1.49 1.21, 1.84 1.39 1.12, 1.72 1.11 0.88, 1.39
        Ptrend <0.001 0.001 0.17
Hip circumference
    Quintile 1 9,656 180 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 8,893 163 0.99 0.80, 1.23 0.97 0.79, 1.20 0.92 0.74, 1.14
    Quintile 3 9,121 162 1.05 0.85, 1.31 1.06 0.85, 1.31 0.99 0.79, 1.22
    Quintile 4 9,549 154 0.96 0.78, 1.19 0.94 0.75, 1.17 0.84 0.68, 1.06
    Quintile 5 8,471 186 1.35 1.10, 1.66 1.26 1.02, 1.55 1.02 0.82, 1.27
        Ptrend 0.02 0.08 0.89
Waist/hip ratio
    Quintile 1 9,719 139 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,378 162 1.21 0.96, 1.51 1.19 0.95, 1.50 1.12 0.89, 1.41
    Quintile 3 8,904 174 1.34 1.07, 1.67 1.31 1.04, 1.63 1.16 0.92, 1.46
    Quintile 4 9,106 175 1.36 1.09, 1.70 1.33 1.06, 1.66 1.19 0.94, 1.49
    Quintile 5 8,584 195 1.64 1.32, 2.04 1.56 1.25, 1.94 1.36 1.08, 1.71
        Ptrend <0.001 <0.001 0.010
Waist/height ratio
    Quintile 1 9,358 144 1.00 Referent 1.00 Referent 1.00 Referent
    Quintile 2 9,560 144 0.97 0.77, 1.22 0.95 0.75, 1.20 0.88 0.70, 1.12
    Quintile 3 9,137 179 1.27 1.02, 1.59 1.25 1.00, 1.55 1.16 0.93, 1.45
    Quintile 4 9,143 172 1.22 0.98, 1.53 1.16 0.93, 1.45 1.01 0.80, 1.28
    Quintile 5 8,483 206 1.63 1.32, 2.02 1.51 1.22, 1.88 1.21 0.96, 1.52
        Ptrend <0.001 <0.001 0.040

Abbreviations: CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio.

a

Sex-specific quintiles as in Tables 3 and 4.

b

Adjusted for age, sex, and race (black, nonblack).

c

Adjusted for age, sex, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), serum creatinine, and hormone replacement therapy (women).

d

Adjusted for age, sex, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), serum creatinine, hormone replacement therapy (women), systolic blood pressure, antihypertensive medication use, diabetes, prediabetes, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, use of aspirin, and high-sensitivity C-reactive protein.

e

Models with and without inclusion of high-sensitivity C-reactive protein yielded similar effect estimates across measures and are therefore not presented separately.