Table 3.

Standardized Mortality Ratios for Noncancer Internal Causes of Death in the Agricultural Health Study Cohort, North Carolina and Iowa, 1993–2007^a

Cause of Death	Applicators (n = 2,743)				Spouses (n = 797)
	Observed	Expected	SMRb	95% CIc	Observed	Expected	SMRb	95% CIc
Blood and blood-forming organs’ diseases	27	40	0.68*	0.45, 0.98	12	13	0.89	0.46, 1.56
Coagulation and hemorrhagic conditions	7	9	0.76	0.31, 1.57	4
Other diseases of blood-forming organs	20	31	0.65	0.40, 1.00	8	10	0.82	0.35, 1.62
Diabetes mellitus	98	242	0.48*	0.33, 0.49	42	95	0.44*	0.32, 0.60
Mental and psychological disorders	33	139	0.24*	0.16, 0.33	9	45	0.20*	0.09, 0.38
Alcoholism	10	46	0.22*	0.10, 0.40	0
Other mental disorders	23	93	0.25*	0.16, 0.37	9	40	0.23*	0.10, 0.43
Nervous system disorders	126	272	0.46*	0.39, 0.55	64	114	0.56*	0.43, 0.72
Multiple sclerosis	0				3
Other nervous system diseases	126	260	0.48*	0.40, 0.58	61	104	0.59*	0.45, 0.76
Heart diseases	1,376	2,569	0.54*	0.51, 0.56	292	620	0.47*	0.42, 0.53
Rheumatic heart disease	8	12	0.69	0.30, 1.36	7	10	0.72	0.29, 1.49
Hypertension with heart disease	40	78	0.52*	0.37, 0.70	7	24	0.29*	0.12, 0.59
Ischemic heart disease	1,099	2,105	0.52*	0.49, 0.55	211	467	0.45*	0.39, 0.52
Chronic diseases of the endocardium	32	50	0.64*	0.44, 0.90	14	20	0.70	0.38, 1.17
Cardiomyopathy	75	109	0.69*	0.54, 0.87	13	27	0.48*	0.26, 0.83
Conductive disorder	61	104	0.59*	0.45, 0.75	22	34	0.64*	0.40, 0.97
Other heart diseases	61	112	0.54*	0.42, 0.70	18	38	0.47*	0.28, 0.75
Other circulatory system diseases	376	731	0.51*	0.46, 0.57	147	270	0.55*	0.46, 0.64
Cerebrovascular disease	236	457	0.52*	0.45, 0.59	105	176	0.60*	0.49, 0.72
Hypertension without heart disease	15	42	0.35*	0.20, 0.58	6	18	0.34*	0.13, 0.74
Diseases of arteries/veins/lymphatic vessels	125	231	0.54*	0.45, 0.64	36	76	0.47*	0.33, 0.65
Respiratory system diseases	346	903	0.38*	0.34, 0.43	92	303	0.30*	0.24, 0.37
Pneumonia	76	192	0.40*	0.31, 0.50	17	58	0.29*	0.17, 0.47
Chronic obstructive pulmonary disease	165	539	0.31*	0.26, 0.36	50	187	0.27*	0.20, 0.35
Asthma	8	10	0.79	0.34, 1.56	4
Other respiratory diseases	97	162	0.60*	0.49, 0.73	21	50	0.42*	0.26, 0.64
Digestive system diseases	125	324	0.39*	0.32, 0.46	50	109	0.46*	0.34, 0.61
Stomach and duodenum diseases	12	21	0.58	0.30, 1.02	5	7	0.72	0.23, 1.68
Hernia and intestinal obstruction	11	19	0.58	0.29, 1.04	2
Cirrhosis and other liver diseases	33	138	0.24*	0.16, 0.34	14	35	0.40*	0.22, 0.67
Other digestive system diseases	69	146	0.47*	0.37, 0.60	29	58	0.50*	0.33, 0.72
Skin and subcutaneous tissue diseases	5	9	0.53	0.17, 1.23	1
Musculoskeletal and connective system diseases	15	30	0.50*	0.28, 0.83	14	24	0.58*	0.32, 0.97
Arthritis and spondylitis	6	12	0.50	0.18, 1.08	6	8	0.73	0.27, 1.59
Other musculoskeletal system diseases	9	18	0.51*	0.23, 0.96	8	16	0.50*	0.21, 0.98
Genitourinary system diseases	69	141	0.49*	0.38, 0.62	28	52	0.53*	0.35, 0.77
Acute glomerulonephritis, renal failure	7	17	0.42*	0.17, 0.86	2
Chronic and unspecified nephritis, renal failure	43	79	0.54*	0.39, 0.73	15	26	0.58*	0.32, 0.96
Other genitourinary diseases	19	46	0.42*	0.25, 0.65	11	21	0.52*	0.26, 0.94
Tuberculosis and human immunodeficiency virus	3				0
Symptomatic and ill-defined conditions	15	40	0.37*	0.21, 0.62	1
Other and unspecified causes	129	252	0.51*	0.43, 0.61	45	98	0.46*	0.33, 0.61

Abbreviations: CI, confidence interval; SMR, standardized mortality ratio.

^*Significant at P = 0.05 based on confidence interval excluding 1.0.

^aAll estimates were adjusted for age, calendar year, gender, race, and state.

^bSMRs were not estimated for <5 observed deaths.

^cCalculated using Byar's approximation to the Poisson exact test.