Table III.
Mutation patterns of Enh II/BCP in HCC and non-HCC patients
| Type | Pattern |
Total (n = 288), n (%) | HCC (n = 152), n (%) | Non-HCC (n = 136), n (%) | P value | OR (95% CI) | |||||
| T1653 | V1753 | T1762 | A1764 | T1766 | A1768 | ||||||
| Wild type | − | − | − | − | − | − | 37 (12.8) | 17 (11.2) | 20 (14.7) | NS | |
| Single mutation | 8 (2.8) | 2 (1.3) | 6 (4.4) | NS | |||||||
| + | − | – | − | − | − | 6 (2.1) | 1 (0.7) | 5 (3.7) | |||
| − | − | + | − | − | − | 1 (0.3) | 0 (0) | 1 (0.7) | |||
| − | − | − | + | − | − | 1 (0.3) | 1 (0.7) | 0 (0) | |||
| Double mutations | 87 (30.2) | 32 (21.1) | 55 (40.4) | 0.000 | 0.393 (0.234–0.660) | ||||||
| − | − | + | + | − | − | 77 (26.7) | 30 (19.7) | 47 (34.6) | |||
| − | − | − | + | + | − | 10 (3.5) | 2 (1.3) | 8 (5.9) | |||
| Triple mutations | 129 (44.8) | 79 (52.0) | 50 (36.8) | 0.01 | 1.861 (1.161–2.984) | ||||||
| + | − | + | + | − | − | 55 (19.1) | 31 (20.4) | 24 (17.6) | |||
| − | + | + | + | − | − | 47 (16.3) | 30 (19.7) | 17 (12.5) | |||
| + | – | − | + | + | − | 7 (2.4) | 5 (3.3) | 2 (1.5) | |||
| − | + | − | + | + | − | 1 (0.3) | 0 (0) | 1 (0.7) | |||
| − | – | + | + | + | − | 2 (0.7) | 2 (1.3) | 0 (0) | |||
| − | − | + | + | − | + | 4 (1.4) | 3 (2.0) | 1 (0.7) | |||
| − | − | − | + | + | + | 13 (4.5) | 8 (5.3) | 5 (3.7) | |||
| Quadruple mutations | 27 (9.4) | 22 (14.5) | 5 (3.7) | 0.002 | 4.434 (1.630–12.063) | ||||||
| + | + | + | + | − | − | 8 (2.8) | 8 (5.3) | 0 (0) | |||
| + | − | + | + | + | − | 3 (1.0) | 3 (2.0) | 0 (0) | |||
| − | + | + | + | + | − | 1 (0.3) | 1 (0.7) | 0 (0) | |||
| + | − | + | + | − | + | 3 (1.0) | 1 (0.7) | 2 (1.5) | |||
| – | + | + | + | − | + | 1 (0.3) | 1 (0.7) | 0 (0) | |||
| + | − | + | − | + | + | 1 (0.3) | 1 (0.7) | 0 (0) | |||
| − | + | + | − | + | + | 2 (0.7%) | 2 (1.3%) | 0 (0%) | |||
| + | – | – | + | + | + | 4 (1.4) | 3 (2.0) | 1 (0.7) | |||
| − | + | – | + | + | + | 3 (1.0) | 1 (0.7) | 2 (1.5) | |||
| − | − | + | + | + | + | 1 (0.3) | 1 (0.7) | 0 (0) | |||
NS, not significant.