Table 1.

Partial correlations between baseline CSF biomarkers and subcortical volumetric reductions and ventricular expansion over 1 year, controlled for the effect of age

	T-tau	P-tau	Aβ1-42	T-tau–Aβ1-42	P-tau–Aβ1-42
Subcortical ROIs
Accumbens	−0.15	−0.16	0.33	−0.37	−0.30
Amygdala	−0.09	−0.29	0.27	−0.32	−0.43
Brainstem	−0.15	−0.14	0.13	−0.30	−0.20
Caudate	−0.07	−0.09	0.33	−0.36	−0.28
Cerebellar gray matter	0.01	−0.06	0.11	−0.16	−0.13
Cerebellar white matter	0.02	−0.19	0.17	−0.13	−0.24
Cerebral white matter	−0.17	−0.26	0.27	−0.40	−0.37
Hippocampus	0.14	−0.07	0.19	−0.07	−0.17
Pallidum	−0.16	−0.25	0.34	−0.36	−0.35
Putamen	−0.09	−0.18	0.38	−0.36	−0.33
Thalamus	−0.11	−0.17	0.37	−0.41	−0.34
Ventricular ROIs
Lateral ventricles	0.13	0.33	−0.33	0.38	0.46
Inferior lateral ventricles	0.16	0.34	−0.30	0.38	0.44
Third ventricle	0.13	0.33	−0.33	0.38	0.46
Fourth ventricle	0.16	0.34	−0.30	0.38	0.44

Note: Values in bold, P < 0.05 (r ≥ 0.24); values in bold and italics, P < 0.001 (r ≥ 0.39). A negative correlation means that higher CSF concentrations are related to more brain atrophy (i.e. negative change in volume) and less ventricular expansion, and a positive correlation means that lower CSF concentrations are related to more atrophy and less ventricular expansion.