Table 2.
Top 20 proteins with the most observed connections in the literature-curated protein database
| Rank | Protein | Obs. | Sig. | Prop. |
|---|---|---|---|---|
| 1 | TP53 | 358 | 6 | 1.2515 |
| 2 | GRB2 | 291 | 3 | 1.0164 |
| 3 | SRC | 277 | 5 | 0.9674 |
| 4 | YWHAG | 249 | 0 | 0.8693 |
| 5 | CREBBP | 231 | 0 | 0.8063 |
| 6 | EGFR | 231 | 5 | 0.8063 |
| 7 | EP300 | 231 | 0 | 0.8063 |
| 8 | PRKCA | 229 | 4 | 0.7993 |
| 9 | MAPK1 | 213 | 4 | 0.7433 |
| 10 | CSNK2A1 | 207 | 1 | 0.7223 |
| 11 | FYN | 205 | 4 | 0.7153 |
| 12 | PRKACA | 202 | 2 | 0.7048 |
| 13 | ESR1 | 200 | 1 | 0.6978 |
| 14 | SHC1 | 195 | 5 | 0.6803 |
| 15 | SMAD3 | 193 | 0 | 0.6733 |
| 16 | STAT3 | 190 | 10 | 0.6628 |
| 17 | SMAD2 | 183 | 1 | 0.6384 |
| 18 | RB1 | 169 | 2 | 0.5894 |
| 19 | TRAF2 | 168 | 2 | 0.5859 |
| 20 | SMAD4 | 166 | 0 | 0.5789 |
To the right of each protein is the observed number of connections, the number of significant connections using P-value of 10−6, and the estimated propensity.