Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Nov 11;31(2):306–312. doi: 10.1161/ATVBAHA.110.216986

Figure 4. Recombinant human IL-11-treated mice show faster recovery of perfusion.

Figure 4

Sv129 mice were pre-treated with rhIL-11 or PBS for 72 hours prior to femoral artery ligation. A. Laser Doppler perfusion imaging of the plantar foot of rhIL-11 treated mice showed increased plantar perfusion and faster blood flow recovery compared with PBS control mice. B. Graph showing ratio of perfusion rate in ligated/non-ligated plantar foot. Recombinant human IL-11 treated mice have significantly increased perfusion rates from day 4 to day 8 after femoral artery ligation. Each time point denotes mean ± SEM of 9 mice. Unpaired student T-test, two tailed *= P< 0.05, **= P< 0.01. Typical region of interest (ROI) used to calculate perfusion rate is marked in white (arrow). C. Laser Doppler perfusion imaging of the adductor region. Increased perfusion through the collaterals in the superficial gracilis muscle is evident on day 4 and 14 in the rhIL-11-treated animal. D. Graph showing ratio of perfusion rate in ligated/non-ligated adductor region. Color scale shows relation between color and units of perfusion rate.