Table 3.
Odds ratios of SCCOOP associated with genotypes in the stratified analysis
| Stratified variables | n (case/control)* |
NEIL1 g.46434077G>T |
P‡ | n (case/control)§ |
NEIL1 g.46438282C>G |
P‡ | n (case/control)|| |
NEIL2 g.4102971G>C |
P‡ | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percentage (case/control) | Adjusted OR (95% CI)† | Percentage (case/control) | Adjusted OR (95% CI)† | Percentage (case/control) | Adjusted OR (95% CI)† | |||||||
| TT | TT vs. GG + GT | GG | GG vs. CC + CG | CC | CC vs. CG + GG | |||||||
| Age | ||||||||||||
| ≤ 50 | 243/303 | 21.0/20.5 | 0.98 (0.64–1.50) | 0.88 | 237/303 | 10.5/7.6 | 1.47 (0.80–2.68) | 0.231 | 236/301 | 19.9/16.9 | 1.25 (0.80–1.95) | 0.376 |
| 51 to 64 | 409/487 | 24.0/20.5 | 1.06 (0.75–1.48) | 0.218 | 404/485 | 9.7/11.1 | 0.89 (0.56–1.42) | 0.473 | 404/484 | 20.8/18.2 | 1.27 (0.90–1.81) | 0.327 |
| ≥ 65 | 217/253 | 20.7/20.9 | 0.92 (0.58–1.46) | 0.955 | 212/253 | 5.7/8.7 | 0.63 (0.30–1.32) | 0.211 | 215/252 | 21.4/15.1 | 1.40 (0.85–2.28) | 0.077 |
| Gender | ||||||||||||
| Male | 671/801 | 23.4/20.5 | 1.11 (0.86–1.43) | 0.176 | 662/800 | 8.6/9.1 | 1.00 (0.69–1.45) | 0.731 | 659/797 | 21.1/17.8 | 1.27 (0.97–1.66) | 0.115 |
| Female | 198/242 | 18.7/21.1 | 0.76 (0.46–1.25) | 0.533 | 191/241 | 9.9/10.8 | 0.86 (0.44–1.66) | 0.776 | 196/240 | 19.4/14.6 | 1.49 (0.87–2.54) | 0.181 |
| Smoking status | ||||||||||||
| Never | 258/502 | 18.6/18.7 | 0.98 (0.67–1.44) | 0.968 | 252/502 | 7.5/10.6 | 0.68 (0.39–1.18) | 0.184 | 251/499 | 19.5/17.6 | 1.13 (0.76–1.66) | 0.528 |
| Former | 320/381 | 20.9/22.6 | 0.91 (0.63–1.31) | 0.602 | 315/379 | 10.5/8.4 | 1.35 (0.81–2.27) | 0.36 | 317/380 | 21.8/16.6 | 1.51 (1.03–2.23) | 0.082 |
| Current | 291/160 | 27.1/21.9 | 1.29 (0.80–2.06) | 0.218 | 286/160 | 8.4/8.8 | 0.96 (0.46–1.97) | 0.897 | 287/158 | 20.6/16.5 | 1.41 (0.83–2.39) | 0.292 |
| Alcohol use | ||||||||||||
| Never | 237/451 | 21.5/20.6 | 1.05 (0.72–1.55) | 0.783 | 234/450 | 9.8/11.1 | 0.87 (0.52–1.47) | 0.606 | 235/449 | 20.9/19.6 | 1.10 (0.74–1.63) | 0.698 |
| Former | 183/168 | 19.7/16.1 | 1.26 (0.72–2.20) | 0.38 | 179/168 | 5.6/10.1 | 0.51 (0.23–1.16) | 0.115 | 181/166 | 18.8/18.7 | 0.97 (0.56–1.69) | 0.979 |
| Current | 449/424 | 23.8/22.4 | 0.98 (0.70–1.37) | 0.618 | 440/423 | 9.8/7.6 | 1.43 (0.87–2.38) | 0.25 | 439/422 | 21.4/13.7 | 1.87 (1.28–2.72) | 0.003 |
| Tumor site | ||||||||||||
| Oral cavity | 297/1043 | 22.6/20.6 | 1.04 (0.75–1.44) | 0.468 | 294/1041 | 7.8/9.5 | 0.83 (0.50–1.36) | 0.375 | 296/1037 | 18.6/17.1 | 1.19 (0.83–1.69) | 0.545 |
| Oropharynx | 572/1043 | 22.2/20.6 | 1.03 (0.80–1.33) | 0.455 | 559/1041 | 9.5/9.5 | 1.04 (0.73–1.49) | 0.985 | 559/1037 | 21.8/17.1 | 1.35 (1.04–1.76) | 0.020 |
The result is bolded if the 95% confidence interval does not include 1 or P < 0.05.
*
No. (cases/controls): 3 cases and 1 control had missing values for NEIL1 g.46434077G>T.
†
Adjusted OR, odds ratios were adjusted for all covariates (age, gender, smoking status, and alcohol use), excluding the stratified variable.
‡
P value was from the χ2 test statistics from comparisons of genotype frequency in cases and controls.
§
No. (cases/controls): 19 cases and 3 controls had missing values for NEIL1 g.46438282C>G.
||
No. (cases/controls) 17 cases and 7 controls had missing values for NEIL2 g.4102971G>C.