Table 4.
Associations between the combined genotypes of the NEIL2 g.4102971 polymorphism and progression of SCCOOP*
| Stratified variables* |
NEIL2 g.4102971G>C |
Crude OR | Adjusted OR † | P‡ | ||
|---|---|---|---|---|---|---|
| n (case/control) | CC | GG+CG | ||||
| Primary tumor (T) | ||||||
| T1 | 216/1037 | 16.2/17.1 | 83.8/82.9 | 0.94 (0.63–1.40) | 0.98 (0.65–1.46) | 0.758 |
| T2 | 315/1037 | 22.5/17.1 | 77.5/82.9 | 1.41 (1.04–1.93) | 1.48 (1.07–2.03) | 0.028 |
| T3 | 159/1037 | 24.5/17.1 | 75.5/82.9 | 1.58 (1.06–2.35) | 1.75 (1.16–2.64) | 0.023 |
| T4 | 165/1037 | 19.4/17.1 | 80.6/82.9 | 1.17 (0.77–1.78) | 1.19 (0.76–1.87) | 0.464 |
| Lymph node metastasis | ||||||
| N0 | 277/1037 | 19.5/17.1 | 80.5/82.9 | 1.18 (0.84–1.65) | 1.24 (0.87–1.77) | 0.346 |
| N1 | 127/1037 | 15.7/17.1 | 84.3/82.9 | 0.91 (0.55–1.50) | 1.01 (0.60–1.69) | 0.708 |
| N2 | 413/1037 | 21.8/17.1 | 78.2/82.9 | 1.35 (1.02–1.80) | 1.40 (1.05–1.88) | 0.036 |
| N3 | 38/1037 | 34.2/17.1 | 65.8/82.9 | 2.53 (1.27–5.03) | 3.06 (1.49–6.26) | 0.007 |
| Combine N and T | ||||||
| N0,1 and T1,2 | 260/1037 | 18.8/17.1 | 81.2/82.9 | 1.13 (0.79–1.60) | 1.19 (0.83–1.72) | 0.500 |
| N2,3 or T3,4 | 595/1037 | 21.5/17.1 | 78.5/82.9 | 1.33 (1.03–1.72) | 1.39 (1.07–1.81) | 0.027 |
Note: The result is bolded if the 95% confidence interval does not include 1 or P < 0.05.
*
Stratified variables: T: The extent of the primary SCCOOP. T1: tumor 2 cm at the greatest dimension; T2 to T4: increasing greatest dimensions. N: regional lymph node involvement. N0: no regional lymph nodes involved; N1 to N3: increasing involvement of regional lymph nodes.
†
Adjusted OR: odds ratios were adjusted for age, gender, smoking status, and alcohol use.
‡
P value from the χ2 test of different frequencies of NEIL2 g.4102971 genotypes in cases and controls.