. 2010 Sep 1;19(2):186–193. doi: 10.1038/ejhg.2010.144

Table 2. Allele frequencies from individual genotyping of 19 SNPs in CNTNAP2 gene region and results of χ²-statistics are shown for the discovery group (160 patients, 80 control individuals), the replication group (610 patients, 364 control individuals) and the combined German groups (770 patients, 444 control individuals).

		Discovery group (160 cases, 80 controls)				Replication group (610 cases, 364 controls)				Combined groups (770 cases, 444 controls)
SNP	Allele	Cases	Controls	χ²	P-value	Cases	Controls	χ²	P-value	Cases	Controls	χ²	P-value	P_c value*
rs13238470	A	0.769	0.744	0.366	0.5452	0.775	0.744	2.288	0.1304	0.773	0.744	2.622	0.1054
rs6973370	A	0.597	0.550	0.963	0.3265	0.619	0.589	1.663	0.1972	0.614	0.582	2.407	0.1208
rs1404699	G	0.437	0.338	4.387	0.0362	0.447	0.411	2.458	0.1170	0.445	0.397	5.206	0.0225
rs700308	T	0.134	0.081	2.921	0.0874	0.139	0.108	4.040	0.0444	0.138	0.103	6.361	0.0117
rs13230403	G	0.362	0.350	0.072	0.7878	0.369	0.374	0.059	0.8085	0.367	0.370	0.014	0.9056
rs4725736	C	0.418	0.278	8.827	0.0030	0.414	0.382	1.990	0.1583	0.415	0.363	6.293	0.0121
rs2107856	T	0.303	0.156	12.138	0.0005	0.288	0.239	5.506	0.0190	0.291	0.224	12.897	0.0003	0.0108
rs2141388	T	0.303	0.156	12.138	0.0005	0.288	0.238	5.905	0.0151	0.291	0.223	13.465	0.0002	0.0072
rs1015932	C	0.712	0.684	0.409	0.5226	0.713	0.696	0.632	0.4265	0.713	0.694	0.977	0.3230
rs7781317	A	0.447	0.419	0.343	0.5582	0.435	0.427	0.122	0.7267	0.437	0.425	0.333	0.5637
rs6970064	G	0.603	0.468	7.754	0.0054	0.577	0.552	1.156	0.2824	0.582	0.537	4.673	0.0306
rs971818	A	0.700	0.677	0.258	0.6116	0.714	0.689	1.318	0.2509	0.711	0.687	1.526	0.2168
rs10226360	C	0.525	0.494	0.422	0.5158	0.528	0.526	0.007	0.9348	0.528	0.520	0.115	0.7344
rs851845	T	0.342	0.325	0.134	0.7144	0.359	0.321	2.793	0.0947	0.355	0.322	2.733	0.0983
rs12703926	A	0.288	0.247	0.879	0.3484	0.238	0.230	0.151	0.6972	0.248	0.233	0.694	0.4049
rs851821	A	0.494	0.469	0.267	0.6054	0.490	0.517	1.275	0.2588	0.491	0.508	0.652	0.4194
rs2074714	A	0.375	0.354	0.192	0.6609	0.356	0.338	0.673	0.4120	0.360	0.341	0.913	0.3394
rs985829	A	0.610	0.577	0.479	0.4891	0.605	0.642	2.618	0.1057	0.606	0.631	1.390	0.2383
rs11975946	G	0.431	0.391	0.681	0.4091	0.407	0.424	0.510	0.4751	0.412	0.418	0.078	0.7805

The SNPs rs2107856 and rs2141388 were initially identified by pooling experiments.

Nominally significant P-values are in bold.

*Pc value: P-value after Bonferroni correction.