Table 1. The summary associations of validated breast cancer risk variants in diverse populations.
| European-Americans 534/541a | African-Americans 539/1022 | Native Hawaiians 146/287 | Japanese 561/550 | Latinos 391/395 | Pooled 2171/2795 | Pintb | |
|---|---|---|---|---|---|---|---|
| Per allele OR (95% CI)c | 1.11 (1.05–1.18) | 1.03 (0.98–1.08) | 1.21 (1.09–1.35) | 1.10 (1.03–1.17) | 1.12 (1.05–1.20) | 1.09 (1.06–1.12) | — |
| P-value | 1.6 × 10−4 | 0.23 | 4.2 × 10−4 | 3.9 × 10−3 | 8.5 × 10−4 | 2.0 × 10−10 | 0.030 |
Abbreviations: OR, odds ratio; CI, confidence interval.
a
Number of cases/controls.
b
P-value for interaction between the summary score and ethnic group (4-df).
c
OR adjusted for age(quartiles), the first 10 eigenvectors from principal components analysis, and race (in pooled analysis).