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Effect of P63 on SP-A regulation of surfactant secretion from type II cells. (Left) Without treatment, SP-A binds to P63 and blocks surfactant release from lamellar bodies. (Right) Preventing SP-A/P63 interactions using anti P63 antibody (Ab) or reduction of P63 protein through siRNA directed against P63 allows surfactant secretion to proceed. LB, lamellar body.
