Table 1.
SP-A Receptors on Type II Cells. Groups presented in chronological order, a, anti-idiotypic antibody, surfactant; b, ligand (SP-A) affinity. column; c, cross-linking; **unconventional myosin 18A; TII, type II pneumocytes; MΦ, macrophages; ND, not done; Ab, antibody; PL, phospholipid; Non-red., non-reduced; Ref, reference; (Yes), SP-A blocked, binding of receptor antibody to type II cells; ^unpublished, Bates.
| Group |
Method of isolation |
Name of antibody or receptor |
Ab to receptor blocks: | ||||||
|---|---|---|---|---|---|---|---|---|---|
| mw (kDa) | On MΦ? |
SP-A binding |
SP-A effect on PL: | Ref. |
|||||
| Non-red. | Reduced | Secretion | Uptake | ||||||
| Strayer | a | ab-A2R/A2C | 210 | 30, 52, 60 | No | Yes | Yes | Yes | [32, 36, 37, 38] |
| Stevens | a | ab-2H5 or Bp55 | 170-200 | 55 | No | Yes | No | Yes | [31, 67] |
| Kresch | b, TII | SPAR | 86 | 86 | |||||
| >200 | 50-65 | No | (Yes) | ND | Yes | [33] | |||
| Chroneos | b, MΦ | SP-R210** | 600 | 210 | Yes | Yes | Yes | ND | [26, 42] |
| Bates/Fisher | c | CKAP4/P63 | 63 | 63 | No | Yes | Yes | Yes^ | [34] |