Table 2.
Ventricular action potential parameters in response to blebbistatin. C: control; B: blebbistatin; CL: cycle length (msec); MDP: maximum diastolic potential (mV); Pmax: maximum upstroke velocity (mV/msec); AP10, AP50 or AP90: action potential duration to 10%, 50% or 90% of repolarization (msec); ERP: effective refractory period (msec). Values are mean ± SEM.
| 1uM (n=4) | 5uM (n=4) | 10uM (n=4) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| C | B | P | C | B | P | C | B | P | |
| CL | 1235 ± 459 | 1610 ± 616 | 0.11 | 1357 ± 400 | 1450 ± 450 | 0.18 | 1411 ± 459 | 1545 ± 414 | 0.53 |
| MDP | −68.0 ± 1.0 | −68.1 ± 1.6 | 0.96 | −68.0 ± 1.7 | −67.4 ± 1.4 | 0.52 | −63.0 ± 1.7 | −67.3 ± 1.4 | 0.80 |
| Pmax | 5.9 ± 1.1 | 6.2 ± 0.9 | 0.58 | 5.4 ± 1.0 | 4.9 ± 0.4 | 0.61 | 4.7 ± 0.2 | 4.2 ± 0.4 | 0.10 |
| AP10 | 149.7 ± 8.6 | 146.3 ± 20.0 | 0.89 | 147.3 ± 22.8 | 133.1 ± 16.2 | 0.12 | 144.0 ± 20.6 | 140.7 ± 11.4 | 0.77 |
| AP50 | 241.8 ± 10.3 | 247.1 ± 18.8 | 0.79 | 246.9 ± 16.3 | 230.9 ± 9.5 | 0.21 | 238.8 ± 16.3 | 233.9 ± 10.9 | 0.67 |
| AP90 | 275.0 ± 9.7 | 281.2 ± 16.2 | 0.76 | 283.2 ± 12.6 | 268.4 ± 8.8 | 0.24 | 274.9 ± 13.9 | 272.9 ± 10.3 | 0.87 |
| ERP* | 307 ± 11.5 | 320 ± 5.0 | 0.55 | ||||||