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. 2011 Jan 6;12:3. doi: 10.1186/1471-2202-12-3

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Copyright ©2011 Soderstrom et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of chronic, developmental, cannabinoid treatments on endogenous 2-AG levels in zebra finch brain. Brains were rapidly dissected into rostral (Rostral Tel.) and caudal (Caudal Tel.) telencephalon, midbrain and cerebellum. Lipids were extracted, spiked with deuterium-labeled internal standards and subjected to LC-ESI-MS-MS for quantitative analysis of 2-arachidonyl glycerol (2-AG) content. (A): ANOVA indicates a significant relationship between brain region and 2-AG content (p < 0.05). Post-hoc analysis reveals a significant increase in 2-AG content in rostral telencephalon (which contains the song regions lMAN and Area X). Significant decreases in endocannabinoid content within cerebellum were observed following developmental WIN (*p < 0.05). (B): No effect of repeated WIN treatments given during adulthood on 2-AG levels were found.