Table 1.
Cytotoxicity was analysed by MTT assay in LNCaP-S14 and IMR90 cells treated with increasing concentrations (0.01 - 40 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h.
| LNCaP-S14 | IMR90 | |
|---|---|---|
| MG132 | 0.379 | 0.445 |
| Thapsigargin | 0.0078 | 0.031 |
| SMIP001 | 4.63 | > 20 |
| SMIP002 | 11.09 | > 40 |
| SMIP003 | 15.92 | 65.36 |
| SMIP004 | 1.09 | > 20 |
| SMIP005 | 1.71 | 17.38 |
| SMIP006 | 6.63 | NT |
| SMIP009 | > 40 | > 40 |
| SMIP011 | > 40 | ~ 40 |
| SMIP012 | 4.59 | ~ 10 |
| SMIP013 | 18.15 | ~ 20 |
| SMIP015 | 13.02 | ~ 20 |
| SMIP016 | 14.63 | 4.41 |
| SMIP017 | 23.73 | > 40 |
| SMIP018 | > 40 | > 40 |
| SMIP019 | NT | ~ 40 |
NT: not tested.
The data in the table represents the IC50 (μM).