Table 1.
Detection of the mtDNA 4,977 bp deletion in tumor and non-tumor tissues of 104 colorectal cancer patients.
| N | Deletion detected in non-tumor tissues | p-value | OR (95% CI) | Deletion detected in tumor tissues | p-value | OR (95% CI) | |
|---|---|---|---|---|---|---|---|
| Cases | 104 | 13 (12.50%) | 17 (16.35%) | ||||
| Age | |||||||
| ≤65 | 48 | 7 (14.58%) | 0.552 | 1.423 | 12 (25.00%) | 0.027* | 3.400 |
| >65 | 56 | 6 (10.71%) | (0.443-4.566) | 5 (8.93%) | (1.101-10.495) | ||
| BMI# | |||||||
| <18 | 3 | 0 | 0.248 | -- | 0 | 0.286 | -- |
| 18-24 | 65 | 8 (11.76%) | 11 (16.18%) | ||||
| ≥24 | 25 | 5 (20.00%) | 6 (24.00%) | ||||
| Differentiation# | |||||||
| Poor | 22 | 2 (9.09%) | 0.772 | 0.590 | 3 (13.64%) | 0.813 | 0.680 |
| Moderate | 69 | 10 (14.49%) | (0.119-2.924) | 13 (18.84%) | (0.175-2.647) | ||
| LN metastasis | |||||||
| Positive | 43 | 8 (18.60%) | 0.114 | 2.560 | 8 (18.60%) | 0.601 | 1.321 |
| Negative | 61 | 5 (8.20%) | (0.775-8.453) | 9 (14.75%) | (0.465-3.753) | ||
| Stage | |||||||
| I+II | 60 | 5 (8.33%) | 0.134 | 0.409 | 9 (15.00%) | 0.665 | 0.794 |
| III+IV | 44 | 8 (18.18%) | (0.124-1.350) | 8 (18.18%) | (0.280-2.255) |
N, case number; BMI, body mass index; Differentiation, tumor cell differentiation status; LN metastasis, lymph node metastasis; Stage, cancer stage classified according to the tumor-node-metastasis (TNM) staging system (American Joint Committee on Cancer); OR, odds ratio; P-values were calculated by chi-square test, * statistically significant; 95% CI, 95% confidence interval; # incomplete data.