Table 4.
Incidence of Suicidal Behavior or Ideation by Treatment Group and Indication
| Indication | Bupropion, n/N (%) | Placebo, n/N (%) | Odds Ratio (95% CI) | P Value |
| All indications | 22/8,953 (0.25)a | 14/6,520 (0.21) | 1.35 (0.68–2.72) | .402 |
| Major depressive disorder | 17/3,179 (0.53) | 11/2,310 (0.48) | 1.28 (0.59–2.86) | .566 |
| Smoking cessation | 2/4,133 (0.05) | 1/2,730 (0.04) | 1.75 (0.13–52.57) | 1.000 |
| Seasonal affective disorder | 1/570 (0.18) | 1/553 (0.18) | 0.99 (0.03–38.73) | 1.000 |
| Relapse prevention trials (major depressive disorder/smoking) | 1/426 (0.23) | 1/429 (0.23) | 1.01 (0.03–39.28) | 1.000 |
a
One event was reported in a bupropion-treated subject in an alcohol dependence trial.