Table 5.

Worsening on the Depressed Mood Item and the Suicide Item of the Rating Scales

Rating Scale and Unit Increase	Depressed Mood Item				Suicide Item
	Bupropion, n/N (%)	Placebo, n/N (%)	Odds Ratio (95% CI)	P Value	Bupropion, n/N (%)	Placebo, n/N (%)	Odds Ratio (95% CI)	P Value
HDRS (17 MDD short-term trials)
≥ 1	196/2,316 (8.5)	125/1,502 (8.3)	0.99 (0.78–1.27)	1.000	337/2,316 (14.6)	233/1,501 (15.5)	0.87 (0.72–1.05)	.148
≥ 2	16/2,316 (< 1)	8/1,502 (< 1)	1.27 (0.53–3.21)	.669	58/2,316 (2.5)	37/1,501 (2.5)	0.94 (0.62–1.46)	.826
SIGH-SAD (3 MDD prevention trials)
≥ 1	378/554 (68.2)	397/541 (73.4)	0.78 (0.60–1.01)	.072	55/554 (9.9)	65/541 (12.0)	0.81 (0.55–1.19)	.288
≥ 2	193/554 (34.8)	225/541 (41.6)	0.75 (0.59–0.96)	.025	10/554 (1.8)	10/541 (1.8)	0.98 (0.39–2.43)	1.000
MADRS (3 MDD trials)
≥ 1	67/594 (11.3)	63/582 (10.8)	1.04 (0.72–1.50)	.853	80/594 (13.5)	74/582 (12.7)	1.06 (0.76–1.49)	.730
≥ 2	13/594 (2.2)	9/582 (1.5)	1.41 (0.59–3.46)	.521	18/594 (3.0)	16/582 (2.7)	1.09 (0.55–2.19)	.863
BDI (4 smoking cessation trials)
≥ 1	141/892 (15.8)	97/555 (17.5)	0.86 (0.64–1.15)	.327	14/892 (1.6)	11/555 (2.0)	0.92 (0.40–2.13)	.837
≥ 2	13/892 (1.5)	4/555 (< 1)	1.90 (0.63–6.89)	.311	0/892 (0.0)	0/555 (0.0)	…	…
IDS (1 MDD trial)
≥ 1	13/133 (9.8)	14/137 (10.2)	0.95 (0.42–2.14)	1.000	14/133 (10.5)	29/137 (21.2)	0.44 (0.22–0.87)	.020
≥ 2	2/133 (1.5)	2/137 (1.5)	1.03 (0.11–10.02)	1.000	1/133 (< 1)	0/137 (0.0)	inf (0.05–inf)	.493

Abbreviations: BDI = Beck Depression Inventory, HDRS = Hamilton Depression Rating Scale, IDS = Inventory of Depressive Symptomatology, inf = infinity, MADRS = Montgomery-Asberg Depression Rating Scale, MDD = major depressive disorder, SIGH-SAD = Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder version.