Table 6.

Improvement (unit decrease ≥ 1) at the Last Evaluable Time Point on the Depressed Mood Item and the Suicide Item of the Rating Scales

	Depressed Mood Item				Suicide Item
Rating Scale	Bupropion, n/N (%)	Placebo, n/N (%)	Odds Ratio (95% CI)	P Value	Bupropion, n/N (%)	Placebo, n/N (%)	Odds Ratio (95% CI)	P Value
HDRS (17 MDD short-term trials)	1707/2,316 (73.7)	1003/1,502 (66.8)	1.56 (1.35–1.81)	< .001	1214/2,316 (52.4)	709/1,501 (47.2)	1.18 (1.03–1.35)	.017
SIGH-SAD (3 MDD prevention trials)	102/554 (18.4)	97/541 (17.9)	1.03 (0.76–1.41)	.876	3/554 (< 1)	2/541 (< 1)	1.47 (0.22–12.44)	.000
MADRS (3 MDD trials)	483/594 (81.3)	454/582 (78.0)	1.23 (0.93–1.64)	.168	289/594 (48.7)	268/582 (46.0)	1.10 (0.88–1.39)	.412
BDI (4 smoking cessation trials)	57/892 (6.4)	28/555 (5.0)	1.12 (0.69–1.83)	.717	20/892 (2.2)	12/555 (2.2)	0.91 (0.43–1.98)	.849
IDS (1 MDD trial)	94/133 (70.7)	88/137 (64.2)	1.34 (0.80–2.25)	.299	61/133 (45.9)	50/137 (36.5)	1.47 (0.90–2.40)	.138

Abbreviations: BDI = Beck Depression Inventory, HDRS = Hamilton Depression Rating Scale, IDS = Inventory of Depressive Symptomatology, MADRS = Montgomery-Asberg Depression Rating Scale, MDD = major depressive disorder, SIGH-SAD = Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder version.