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. 2011 Jan 24;6(1):e16331. doi: 10.1371/journal.pone.0016331

Figure 3. The Absence of ENT1 Increases the Development of Alcohol Withdrawal Seizure in Mice.

Figure 3

(A) Handling induced convulsion scores during the 30 h-period following removal from ethanol vapor chambers. ENT1 null mice had higher scores than wild type mice at 8 h after the ethanol withdrawal (*P<0.05, Tukey test). Area under the curve analysis also shows the increased withdrawal seizure in ENT1-null mice compared to wild-type littermates (*P<0.05, two-tailed t-test). For each genotype, n = 9. (B) Reduced adenosine levels in the striatum of ENT1 null mice compared to wild-type littermates (*P<0.05, two-tailed t-test). For each genotype, n = 8. All data are expressed as mean ± SEM.