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. 2011 Jan 24;6(1):e16441. doi: 10.1371/journal.pone.0016441

Table 1. Sequences, Contour Lengths, and MICs of HP(2–20) and Its Four Analogures.

AMP Sequence* MIC (µM) Contour length (nm)
C.albicans S.aureus E.coli
Ref.31 Ref.8 Ref.31 Ref.8 Ref.31 Ref.8
HP(2–20) AKKVFKRLEKLFSKIQNDK >25 25 12.5 6.25 3.13 6.25 3.20±0.05
HPA1 AKKVFKRLEKLFSKIQNWK 25 25 3.13 3.12 0.78 3.12 2.93±0.03
HPA2 AKKVFKRLEKLFSKIWNDK 25 25 6.25 3.12 3.13 3.12 2.96±0.07
HPA3 AKKVFKRLEKLFSKIWNWK 12.5 6.25 1.56 0.78 1.56 1.56 3.16±0.06
HPA5 AKKVSKRLEKLFSKIQNDK >25 >100 >12.5 50 6.25 6.25 2.91±0.05

*The italic letters in the sequence column indicate the substituted amino acid residues;

The MIC of bacterial growth were measured in low-salt buffer;

The original contour lengths were presented as mean±SE of five different lengths measured from five random conformations in equilibrium for each peptide.