Fig. 1.

Cancer Stem Cell Hypothesis. Solid tumors are maintained by a small group of chemo and radiation resistant cell. These cells possess stem cell like properties such as self-replication and differentiation. Conventional therapy helps with debulking the tumor, however, presence of CSCs in the residual tumor leads to recurrence. Goal of novel stem cell targeted therapy is to eradicate the population of CSC and the absence of tumor sustaining CSCs will lead to tumor eradication