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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Stem Cell Rev. 2011 Mar;7(1):119–129. doi: 10.1007/s12015-010-9132-7

Fig. 2.

Fig. 2

p53 and Rb alteration by adenoviral genome. Adenoviral E1A protein binds to Rb and releases Rb inhibition of E2F. E2F starts G1 to S transition of the cell, directly activates E2 viral gene and activates p14ARF, an inhibitor of the oncoprotein MDM2. MDM2 targets tumor suppressor p53 for destruction. Adenovirus E1B targets p53 for destruction, because in the presence of p53, viral replication cannot occur