| 1991 |
2:1 randomized trial |
Gross total resection plus radiation at 45 Gy Vs 60 Gy |
Median survival increases from 9 months to 12 months |
[104] |
| 2002 |
Meta-analysis |
Gross total resection plus radiation vs. radiation plus chemotherapy |
Addition of chemo led to absolute improvement of 6% at 1 year and 5% at 2 years leading to increased overall survival from 40 to 46% and 15 to 20%, respectively |
[105] |
| 2003 |
Phase III trial |
Gross total resection plus placebo wafer vs. gliadel wafer plus radiation |
Median survival increases from 11.6 months to 13.9 months |
[106] |
| 2005 |
Phase III trial |
Gross total resection plus radiation +/− TMZ |
Median survival increases from 12.1 months to 14.6 months |
[3] |
| 2005 |
Phase III trial |
Analysis of MGMT methylation status in Gross total resection plus radiation +/− TMZ |
Median survival increases from 15.3 to 21.7 with TMZ in the group with methylated MGMT promoter |
[30] |
