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(A) DENV genome including the 5’ and 3’ UTR (untranslated region), the 5’ cap, and the structural (C [capsid], PrM [premembrane] E [envelope]) and nonstructural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5) genes. (B) Schematic representation of the DEN2V protease expression construct (DEN2V NS2B-NS3pro) which includes the central hydrophilic domain of NS2B (cofactor) and the N-terminal protease domain of NS3.
