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Trypsin inhibition constants from kinetic studies.
| Compound | Ki1 trypsin (µM) | Ki2 trypsin (µM) | Mechanism |
|---|---|---|---|
| ARDP0006 | - | 13 ± 0.1 | Uncompetitive |
| 6A42 | 60 ± 13 | 167 ± 20 | Mixed |
| 6A45 | 0.6 ± 0.07 | - | Competitive |
| 6A47 | 4 ± 0.7 | 25 ± 3 | Mixed |
| 6A49 | - | - | No inhibition |
| Benzamidine | 21.6 ± 1 | - | Competitive |
