Figure 3. Treatment of a 5-HT_2C inverse agonist, a 5-HT_1A agonist, or a BZD antagonist into either the dorsal raphe or the amygdala on sensitization of alcohol withdrawal-induced anxiety-like behavior.

Dorsal Raphe data are at the top and amygdala data are presented in the bottom illustration. The 5-HT_2C inverse agonist (SB243213; SB), the 5-HT1A agonist (buspirone), and the BZD antagonist (Flumazenil; Flu) were administered into the sites during withdrawal from the initial two cycles. Social interaction as a measure of anxiety-like behavior was measured 5–6 hrs after withdrawal from the final cycle of alcohol. * P < 0.01 compared to control diet exposure. Modified from Overstreet et al (2006) and Knapp et al. (2007) by permission of the publishers.