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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pharmacol Ther. 2010 Oct 15;129(2):149–171. doi: 10.1016/j.pharmthera.2010.09.007

Figure 4. Repeated Stresses Sensitization of alcohol (ET) withdrawal-induced anxiety.

Figure 4

The (Control Diet) group received only diet. The (No Stress-1 cycle ET) group received no stress and and only 1 cycle ET. The (Control Diet-3 Stress) group received 3 separate 60 min stresses at weekly intervals. The (2 Stresses—1 cycle ET) group was exposed to two 60 min restraint stresses at a weekly interval followed by exposure to 1 cycle of 5 days of 4.5% alcohol diet. Social interaction as a measure of anxiety was measured 5–6 hrs after removal of alcohol diet or the final stress. * P < 0.01 compared to all other groups. From Breese et al. (2004) by permission of publisher.