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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pharmacol Ther. 2010 Oct 15;129(2):149–171. doi: 10.1016/j.pharmthera.2010.09.007

Figure 5. A CRF1R antagonist, a BZD receptor antagonist and a 5-HT1A agonist prevent the repeated stress sensitization of alcohol (ETOH) withdrawal anxiety.

Figure 5

The CRF1R antagonist was CRA1000, the BZD antagonist was flumazenil (FLU) and the 5-HT1A agonist was buspirone. For each of the drug groups the drug was administered prior to each stress given prior to 5 days of 4.5% ethanol diet (ETOH) Social interaction as a measure of anxiety-like behavior was measured 5–6 hrs after ETOH Diet removal. * P < 0.01 compared to all other groups. From Breese et al. (2004) by permission of publisher.