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. Author manuscript; available in PMC: 2011 Apr 20.
Published in final edited form as: Sci Transl Med. 2010 Oct 20;2(54):54ra76. doi: 10.1126/scitranslmed.3001079

Fig 3. Focal restoration of NAcc p11 via AAV gene therapy reverses depression-like behaviors in transgenic p11 KO mice.

Fig 3

(A) Immobility times on tail suspension test following AAV gene therapy to restore NAcc p11 expression (hatched bars). Depression-like behaviors were reversed in these animals compared with both untreated mice (filled bars) and control AAV-treated mice (open bars). (B) Immobility times on the forced swim test in the same animals as in fig. 3A. (C) Increased sucrose preference in p11 KO mice following restoration of NAcc p11 expression. Volume of sucrose intake over 24 hrs. per gram of body weight was significantly increased in p11 KO mice compared with controls while there was no significant difference between groups in water intake. The percent of sucrose as a measure of overall fluid intake was also significantly increased (not shown). **p<0.01, ***p<0.005, two-tailed t-test.