Table 3.
Optimal tracers for net (→) and exchange (↔) fluxes for the A549 carcinoma cell
Glycolysis | |
---|---|
Reaction | Best Tracer(s) |
Glucext → G6P | [1,2] & [2]Gluc |
G6P → F6P | [1,2]Gluc |
G6P ↔ F6P | [3] & [3,4]Gluc |
F6P → DHAP + GAP | [1,2] & [2]Gluc |
DHAP → GAP | [1,2]Gluc |
DHAP ↔ GAP | [1,2]Gluc |
GAP → 3PG | [1,2] & [2]Gluc |
GAP ↔ 3PG | none |
3PG → Pyr | [1,2]Gluc |
Pyr → Lac | [1,2] & [2]Gluc |
Pyr ↔ Lac | none |
Lac → Lac.x | [1,2] & [2]Gluc |
Pentose Phosphate Pathway | |
---|---|
Reaction | Best Tracer(s) |
G6P → 6PG | [1,2]Gluc |
6PG → P5P + CO2 | [1,2]Gluc |
2 P5P → S7P + GAP | [1,2] & [3]Gluc |
2 P5P ↔ S7P + GAP | [1,2]Gluc |
S7P + GAP → F6P + E4P | [1,2]& [3]Gluc |
S7P + GAP ↔ F6P + E4P | [1,2]Gluc |
P5P + E4P → F6P + GAP | [1,2] & [3]Gluc |
P5P + E4P ↔ F6P + GAP | [1,2] & [3]Gluc |
TCA Cycle/Anaplerosis | |
---|---|
Reaction | Best Tracer(s) |
Pyr + CO2 → OAA | [U]Gln |
Mal → Pyr + CO2 | [U] & [3,4]Gln |
Mal ↔ Pyr + CO2 | [U]Gln |
Pyr → AcCoAmit + CO2 | [U]Gln |
AcCoAmit + OAA → Cit | [U]Gln |
AKG + CO2 → Cit | [U], [1,2] & [3,4]Gln |
AKG + CO2 ↔ Cit | [U]Gln |
AKG → Suc + CO2 | [U] & [3,4]Gln |
Suc → Fum | [U] & [3,4]Gln |
Suc ↔ Fum | [U] & [1,2]Gln |
Fum → Mal | [U] & [3,4]Gln |
Fum ↔ Mal | [U]Gln |
OAA → Mal | [U]Gln |
OAA ↔ Mal | [U]Gln |
Amino Acid Metabolism | |
---|---|
Reaction | Best Tracer(s) |
Glnext → Gln | [3], [U] & [3,4]Gln |
Gln → Glu | [3], [U] & [3,4]Gln |
Glu → AKG | [3], [U] & [3,4]Gln |
Glu ↔ AKG | [U]Gln |