Table 4.

Risk Factors for Quantity of Coronary Artery Calcified Plaque in the Combined Cohort of Persons with Diabetes

	MODEL 1 Adjusted for Age, Study, Race, Sex, and Race X Sex			MODEL 2 Fully Adjusted Model *
	Difference in [log (CAC +1)]	95% Confidence interval	p-value	Difference in [log (CAC +1)]	95% Confidence interval	p-value
Age (yrs) For 10 years	1.09	[0.98,1.20]	<0.0001	1.04	[1.03,1.06]	<0.0001
Race X Sex (ref., white males)	Black female: −2.15	[−2.78,−1.51]	<0.0001	Black female: −1.98	[−2.05,−1.92]	<0.0001
	Black male: −1.25	[−1.61,−0.89]		Black male: −1.21	[−1.61,−0.81]
	White female: −1.69	[−1.96,−1.41]		White female: −1.41	[−1.74,−1.08]
Study (ref., MESA)	DHS: 0.99	[0.71,1.26]	<0.0001	DHS: 0.64	[0.33,0.95]	<0.0001
	FHS: 0.44	[0.09,0.79]	0.01	FHS: 0.43	[0.07,0.79]	0.02
HbA1c (%) †	0.07	[0.008,0.14]	0.03	0.06	[−0.01,0.14]	0.09
Duration of diabetes (yrs) For 10 years	0.36	[0.22,0.51]	<0.0001	0.46	[0.30,0.61]	<0.0001
LDL (mg/dL) For 20 mg/dl	−0.02	[−0.08,0.05]	0.63	0.02	[−0.05,0.09]	0.83
HDL (mg/dL) For 15 mg/dl	−0.07	[−0.21,0.06]	0.30	−0.06	[−0.21,0.09]	0.45
TG (mg/dL) For 135 mg/dl	0.07	[−0.03,0.17]	0.16	0.01	[−0.22,0.23]	0.95
CRP(mg/dL) For 10 mg/dl	−0.10	[−1.06,0.86]	0.83	−0.04	[−1.02,0.93]	0.38
Pack-years For 10 pack-yrs	0.14	[0.09,0.18]	<0.0001	0.10	[0.05,0.16]	<0.0001
Current smoker (ref., non-smoker)	0.91	[0.62,1.20]	<0.0001	0.73	[0.39,1.08]	<0.0001
Hypertension	0.53	[0.27,0.80]	<0.0001	0.42	[0.13,0.72]	0.005
BMI (kg/m2)	0.01	[−0.00,0.03]	0.12	0.01	[−0.00,0.03]	0.20

^*Fully adjusted model includes age, study, race, sex, race X sex, duration of diabetes, LDL, HDL, TG, pack-years, current smoker, hypertension, CRP, and BMI.

^†Models of HbA1c are restricted to the MESA and DHS studies.