Table 4.
MODEL 1 Adjusted for Age, Study, Race, Sex, and Race X Sex |
MODEL 2 Fully Adjusted Model * |
|||||
---|---|---|---|---|---|---|
Difference in [log (CAC +1)] |
95% Confidence interval |
p-value | Difference in [log (CAC +1)] |
95% Confidence interval |
p-value | |
Age (yrs) For 10 years | 1.09 | [0.98,1.20] | <0.0001 | 1.04 | [1.03,1.06] | <0.0001 |
Race X Sex (ref., white males) | Black female: −2.15 | [−2.78,−1.51] | <0.0001 | Black female: −1.98 | [−2.05,−1.92] | <0.0001 |
Black male: −1.25 | [−1.61,−0.89] | Black male: −1.21 | [−1.61,−0.81] | |||
White female: −1.69 | [−1.96,−1.41] | White female: −1.41 | [−1.74,−1.08] | |||
Study (ref., MESA) | DHS: 0.99 | [0.71,1.26] | <0.0001 | DHS: 0.64 | [0.33,0.95] | <0.0001 |
FHS: 0.44 | [0.09,0.79] | 0.01 | FHS: 0.43 | [0.07,0.79] | 0.02 | |
HbA1c (%) † | 0.07 | [0.008,0.14] | 0.03 | 0.06 | [−0.01,0.14] | 0.09 |
Duration of diabetes (yrs) For 10 years | 0.36 | [0.22,0.51] | <0.0001 | 0.46 | [0.30,0.61] | <0.0001 |
LDL (mg/dL) For 20 mg/dl | −0.02 | [−0.08,0.05] | 0.63 | 0.02 | [−0.05,0.09] | 0.83 |
HDL (mg/dL) For 15 mg/dl | −0.07 | [−0.21,0.06] | 0.30 | −0.06 | [−0.21,0.09] | 0.45 |
TG (mg/dL) For 135 mg/dl | 0.07 | [−0.03,0.17] | 0.16 | 0.01 | [−0.22,0.23] | 0.95 |
CRP(mg/dL) For 10 mg/dl | −0.10 | [−1.06,0.86] | 0.83 | −0.04 | [−1.02,0.93] | 0.38 |
Pack-years For 10 pack-yrs | 0.14 | [0.09,0.18] | <0.0001 | 0.10 | [0.05,0.16] | <0.0001 |
Current smoker (ref., non-smoker) | 0.91 | [0.62,1.20] | <0.0001 | 0.73 | [0.39,1.08] | <0.0001 |
Hypertension | 0.53 | [0.27,0.80] | <0.0001 | 0.42 | [0.13,0.72] | 0.005 |
BMI (kg/m2) | 0.01 | [−0.00,0.03] | 0.12 | 0.01 | [−0.00,0.03] | 0.20 |
Fully adjusted model includes age, study, race, sex, race X sex, duration of diabetes, LDL, HDL, TG, pack-years, current smoker, hypertension, CRP, and BMI.
Models of HbA1c are restricted to the MESA and DHS studies.