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. 2010 Oct 19;43(1):24–31. doi: 10.1152/physiolgenomics.00172.2010

Fig. 1.

Fig. 1.

Membrane permeability in limb-based skeletal muscle is modified by a single major locus on chromosome 7. Genomewide association scans were performed correlating membrane permeability in Sgcg mice, a model of muscular dystrophy. Sgcg mice on a mixed genetic background of DBA/2J and 129/SVEMS+/J were used for mapping. Membrane permeability was measured as Evans blue dye uptake into individual muscle groups. A single locus on chromosome 7, DMOD1, regulates dye uptake in quadriceps, gastrocnemius/soleus, gluteus/hamstring, and triceps muscles. Autosomal chromosomes and the 330 informative single nucleotide polymorphism (SNP) markers used are plotted on the x-axis; logarithm of odds (LOD) scores are represented on the y-axis. The same region on chromosome 7 was tightly associated with membrane permeability in all 4 muscles, with peak LOD scores of 25.94 in quadriceps, 10.24 in gastrocnemius/soleus, 8.60 in gluteus/hamstring, and 6.12 in triceps. No other regions of the genome reached significance.