Fig. 3.
Fibrosis in quadriceps muscles is modified by DMOD1 on chromosome 7. A genomewide association scan for quadriceps collagen content was carried out with 270 SgcgD2/129 F2 progeny. Hydroxyproline (HOP) content was determined as a measure of collagen content. Autosomal chromosomes and the 330 informative SNP markers used are plotted on the x-axis; LOD scores are represented on the y-axis. A region on chromosome 7, DMOD1, showed highly significant association with HOP content in quadriceps, with a peak LOD score of 6.89.