Fig. 4.
Fibrosis in the diaphragm and abdominal muscles is modified by a locus on chromosome 3, DMOD3. Genomewide association scans for fibrosis in SgcgD2/129 F2 progeny were performed in the diaphragm (n = 272) and abdominal (n = 270) muscles. Autosomal chromosomes and the 330 informative SNP markers used are plotted on the x-axis; LOD scores are represented on the y-axis. Overlapping regions on chromosome 3 showed highly significant association with fibrosis in diaphragm and in the abdominal muscles. The peak LOD score in the diaphragm interval was 6.55; the peak LOD score for the abdominal interval was 4.39. An additional locus, DMOD4, contributing to abdominal HOP content was identified on chromosome 10 with a peak LOD of 3.71.