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Fibrosis in cardiac muscle is modified by a locus on chromosome 9, DMOD5. A genomewide linkage scan for heart ventricle HOP content in 265 SgcgD2/129 F2 progeny was performed. Autosomal chromosomes and the 330 informative SNP markers used are plotted on the x-axis; LOD scores are represented on the y-axis. An ∼20-Mb region on chromosome 9 showed significant linkage to HOP content in the heart with a peak LOD score of 4.12.
