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. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Neuroimage. 2010 Oct 26;54(3):1903–1909. doi: 10.1016/j.neuroimage.2010.10.064

The concentrations of radioactivity in lateral temporal cortex from a typical healthy subject were fitted with a one- and an unconstrained two-tissue compartment model. The two-tissue compartment model () more closely followed the measured values than did the one-compartment model ().The values of V_T were 0.668 mL/cm³ from the one-tissue compartment model and 0.756 mL/cm³ from the two-tissue compartment model. Weighting using Noise Equivalent Counts is influenced by radioactive decay, and that explains the slight deviation of the two-tissue compartment model to the measured data at late time-points. Brain data for this region were also quantified with the Logan method using either the arterial input function or the image input function. The values of V_T (derived from the slope of the lines) were similar for both inputs: 0.781 mL/cm³ for arterial and 0.783 mL/cm³ for image.

Inline graphic — The concentrations of radioactivity in lateral temporal cortex from a typical healthy subject were fitted with a one- and an unconstrained two-tissue compartment model. The two-tissue compartment model () more closely followed the measured values than did the one-compartment model ().The values of V_T were 0.668 mL/cm³ from the one-tissue compartment model and 0.756 mL/cm³ from the two-tissue compartment model. Weighting using Noise Equivalent Counts is influenced by radioactive decay, and that explains the slight deviation of the two-tissue compartment model to the measured data at late time-points. Brain data for this region were also quantified with the Logan method using either the arterial input function or the image input function. The values of V_T (derived from the slope of the lines) were similar for both inputs: 0.781 mL/cm³ for arterial and 0.783 mL/cm³ for image.