Table 1.

Distribution volume calculated from compartmental rate constants are similar to the distribution volume calculated with Logan plot in 12 healthy subjects.

	Compartmental rate constants *				Compartmental distribution volume *	Logan distribution volume *
Region	K1 (mL • cm−3 • min−1)	k2 (min−1)	k3 (min−1)	k4 (min−1)	VT (mL • cm−3)	VT (mL • cm−3)
Frontal Cortex	0.058 ± 0.013 (3.1 %)	0.18 ± 0.04 (6.9%)	0.049 ± 0.024 (12%)	0.041 ± 0.017 (10.2%)	0.73 ± 0.18 (2.8%)	0.70 ± 0.13
Temporal Cortex	0.058 ± 0.011 (3.5%)	0.17 ± 0.03 (7.3%)	0.038 ± 0.017 (16.1%)	0.037 ± 0.015 (14.1%)	0.72 ± 0.16 (3.4%)	0.69 ± 0.12
Medial Temporal Cortex	0.030 ± 0.001 (5.1%)	0.15 ± 0.03 (11.8%)	0.045 ± 0.022 (23.9%)	0.041 ± 0.018 (20.1%)	0.60 ± 0.22 (6.5%)	0.55 ± 0.11
Parietal Cortex	0.056 ± 0.011 (3.1 %)	0.18 ± 0.03 (6.4%)	0.044 ± 0.021 (12.0%)	0.039 ± 0.015 (9.2%)	0.67 ± 0.12 (2.2%)	0.66 ± 0.11
Occipital Cortex	0.066 ± 0.020 (7.1%)	0.24 ± 0.04 (13.6%)	0.048 ± 0.034 (23.1%)	0.041 ± 0.017 (19.5%)	0.59 ± 0.14 (5.4%)	0.58 ± 0.11
Anterior Cingulum	0.052 ± 0.014 (7.0%)	0.19 ± 0.04 (14.7%)	0.054 ± 0.033 (25.6%)	0.043 ± 0.021 (21.5%)	0.64 ± 0.19 (6.5%)	0.61 ± 0.13
Caudate	0.055 ± 0.011 (7.5%)	0.18 ± 0.04 (17.6%)	0.056 ± 0.036 (36.6%)	0.052 ± 0.029 (26.1%)	0.68 ± 0.25 (7.4%)	0.62 ± 0.12
Putamen	0.067 ± 0.013 (5.7%)	0.19 ± 0.03 (13.0%)	0.046 ± 0.028 (31.5%)	0.055 ± 0.026 (20.9%)	0.69 ± 0.15 (3.8%)	0.67 ± 0.12
Thalamus	0.055 ± 0.011 (4.8%)	0.16 ± 0.03 (13.0%)	0.051 ± 0.036 (31.8%)	0.065 ± 0.036 (21.8%)	0.66 ± 0.19 (5.1 %)	0.63 ± 0.13
Cerebellum	0.060 ± 0.012 (2.8%)	0.20 ± 0.03 (5.8%)	0.039 ± 0.025 (16.6%)	0.061 ± 0.037 (13.5%)	0.52 ± 0.13 (3.1 %)	0.52 ± 0.11

Values are mean ± SD from twelve human subjects each having two scans.

For each brain region, standard errors are listed in parentheses and are expressed as % of the variable itself.

^*Compartmental rate constants and distribution volumes are calculated from 90 min of brain and plasma data.