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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Neuroimage. 2010 Oct 26;54(3):1903–1909. doi: 10.1016/j.neuroimage.2010.10.064

Table 2.

Retest and intersubject variability of brain uptake, arterial input function, distribution volume, and plasma free fraction

Variability Brain Uptake
(AUC0–90)		 Arterial Input
(AUC0–90)		 Distribution
Volume (VT)		 Plasma Free
Fraction (fP)
Retest 12.9% 10.2% 18.8% 12.8%
Intersubject (COV) 18.5% 24.8% 25.0% 12.3%

Retest variability is the difference between test and retest studies expressed as a percentage of the mean of test and retest. Intersubject variability is the coefficient of variation (COV) in 12 subjects and is expressed as a percentage.

Brain uptake and arterial input were calculated with the trapezoidal rule for data from 0 to 90 min. Distribution volume (VT) was calculated using compartmental modeling of 90 min of data from both brain and plasma.