Figure 7.

Proposed scheme showing the possible deamination/bypass pathways leading to C→T and CC→TT pathways at an AC^mCG site. Black arrows refer to chemical steps, red arrows to excision repair steps, blue arrows to pol η bypass steps, and dotted arrows to either excision repair, or replication of the undamaged strand. The thickness of the arrows represents the relative rates of deamination (experimentally determined) or repair (proposed). Values in italics are the experimentally determined half lives in hours at 37°C.