Table 1.
Cis-syn cyclobutane dimer photoproduct yield and deamination half life.
entry | Abbrev. | Py=Py | Flanking N | sequencea | % yield | t1/2 (h) | |
---|---|---|---|---|---|---|---|
1 | Double | GTmCG | T=mC | G--G | tGT=mCGtc | 5.4 | 5.8 ± 0.6 |
2 | Strand | GTCG | T=C | G--G | tGT=CGtc | 1 | 4.9 ± 0.8 |
3 | ITCI | T=mC | I--I | tIT=mCItc | 29 | 14.1 ± 0.8 | |
4 | aPTmCaP | T=mC | aP--aP | taPT=mCaPtc | 2.8 | 43 ± 2 | |
5 | ATmCA | T=mC | A--A | tAT=mCAtc | 17 | 175 ± 1 | |
6 | ATCA | T=C | A--A | tAT=CAtc | 7 | 46 ± 1.4 | |
7 | GmCTG | mC=T | G--G | tGmC=TGgc | 3.4 | 20.0 ± 0.5 | |
8 | AmCTA | mC=T | A--A | tAmC=TAgc | 7.8 | ~500 | |
9 | GTmCA | T=mC | G--A | tGT=mCAtc | 8.8 | 230 ± 18 | |
10 | ATmCG | T=mC | A--G | tAT=mCGtc | 12 | 7.1 ± 0.2 | |
11 | ATCG | T=C | A--G | tAT=CGtc | 5 | 5.3 ± 0.5 | |
12 | TTmCTT | T=mC/mC=T | T--T | tTTmCTtc | 15.7 | 385 ± 40 | |
13 | CCmCCC | C=mC/mC=C | C--C | tCCmCCcc | 6 | 300 ± 40 | |
14 | GTmCGGG | T=mC | G--GGG | tGT=mCGgg | 3.3 | 5.5 ± 0.5 | |
15 | GGGTmCG | T=mC | GGG--G | gGT=mCGtc | 3.9 | nd | |
16 | Single | GTmCG | TmC | G--G | tGT=mCGtc | 5.3 | 3.5 ± 0.1 |
17 | Strand | ATmCA | TmC | A--A | tAT=mCAtc | 7.8 | 4.2 ± 0.2 |
18 | GmCTG | mCT | G--G | tGmC=TGgc | 3.4 | 10.7 ± 0.6 | |
19 | AmCTA | mCT | A--A | tAmC=TAgc | 7.3 | 12.1 ± 0.4 |
The sequence shown is embedded in the 42-mer single strand sequence: d(GTGTATGTATGTGTATGnNXYNnnGTGTATATATGTGTATGT). The double strand sequence is formed by annealing to its fully complementary strand. I: inosine, aP: 2-aminopurine, and mC: 5-methylcytosine.