. Author manuscript; available in PMC: 2011 Jan 25.

Published in final edited form as: J Mol Biol. 2009 Jul 22;392(5):1145–1157. doi: 10.1016/j.jmb.2009.07.048

Table 3.

Analysis of mutation spectra of non-XP, squamous cell and basal cell carcinomas of the skin at 11 Py^mCG sites from the p53 database.^a

^mCG codon	non-transcribed /transcribed^b	CC→TC	CC→CT	CC→TT	TC→TT	XPC
152	CCG/na	8/na
158	CCG/na		1/na	1/na
196	CCG/TCG		13/0	2/0		2/0
213	TCG/TCG				3/0
245	na/CCG	na/2	na/5	na/2
248	CCG/CCG		12/9	9/1		6/0
282	CCG/CCG		9	13		6/0
Total	11 sites	10	45	28	3	14

Data from: IARC TP53 Mutation Database (http://www-p53.iarc.fr/) (ref ³⁸). Non-XP Basal cell carcinoma data from: Basal cell carcinoma NOS (C44._) data set restricted to the skin with XP germline mutations filtered out. Non-XP Squamous cell carcinoma data from: Squamous cell carcinoma NOS data set restricted to the skin and with XP germline mutations excluded.

Both the transcribed and non-transcribed strands contain a ^mCG sequence. If the strand contains a Py^mCG sequence capable of dimer-mediated C→T mutations, the sequence is given. If the strand does not contain a Py^mCG sequence, the abbreviation na for not applicable is given.