Skip to main content
. 2011 Feb 1;4(1):47–58. doi: 10.1593/tlo.10217

Figure 5.

Figure 5

STAT/SRC-related mRNA expression profiles were associated with response to treatment in LA-SCCHN. In A, a high expression of STAT5A and/or EPHA2 was associated with complete response to CTX-based treatments. Most tumors from patients who performed best on CTX-based treatments (12/15 [80%]) expressed high levels of STAT5A and/or high levels of EPHA2 (P < .0001; odds ratio = 58.67; 95% CI = 5.4–64.5; positive predictive value = 1, negative predictive value = 0.8) as assessed by using the upper RQ value quartile (75% percentile). This high STAT5A/EPHA2 pattern was further associated with prolonged PFS (HR = 9.44, 95% CI = 6.48–12.40) but not with patient overall survival, as shown in B. In C, the proposed dasatinib response-predictive signature with high ANXA1/CAV1/EPHA2 and low IGFBP2 was seldom encountered in LA-SCCHN (red dots). Cases are listed in the same order in the three panels. According to the definition of high and low (upper quartile, median, and lower quartile cutoffs for RQ values), different tumors seemed positive for this profile, some of which responded completely to CTX-based treatments. Panels in A and C: ▪ = high; □ = low RQ values.