Table 1.
GAL/MEL genes of S. cerevisiae and GAL/LAC genes of K. lactis
| S. cerevisiae | K. lactis | ||
| Gene | Function | Gene | Function |
| Structural/Catabolic genes | Structural/Catabolic genes | ||
| MEL1 | α-Galactosidase | LAC12 | Lactose/galactose permease |
| GAL2 | Galactose permease | LAC4 | β-Galactosidase |
| GAL1a | Bifunctional galactokinase/sensor inducer | KlGAL1a | Bifunctional galactokinase/sensor inducer |
| GAL10 | Uridine diphosphoglucose 4-epimerase | KlGAL10 | Uridine diphosphoglucose 4-epimerase |
| GAL7 | Galactose-1-phosphate uridylyltransferase | KlGAL7 | Galactose-1-phosphate uridylyltransferase |
| GAL5b | Phosphoglucomutase | KlGAL5b | Phosphoglucomutase |
| Regulatory genes | Regulatory genes | ||
| GAL4 | Transcriptional activator | KlGAL4 (LAC9) | Transcriptional activator |
| GAL80 | Gal4p repressor | KlGAL80 | Gal4p repressor |
| GAL3 | Gal80p repressor (sensor/inducer) | ||
a
GAL1 has both catabolic (galactokinase) and regulatory (sensor/inducer) functions.
b
GAL5 is not specific of the GAL regulon, having a more generalized role in carbon metabolism.