. Author manuscript; available in PMC: 2011 Jan 25.

Published in final edited form as: Am J Ophthalmol. 2009 Dec 30;149(3):513–522. doi: 10.1016/j.ajo.2009.09.024

Table 3.

Sequence Alterations Identified in PON1 in AMD Patient and Control Populations.

Exon	Sequence Change	Protein Change	Allele Frequency AMD Patients	Allele Frequency Normals
3	TTG→ATG	Leu55Met	693/1838 = 37.70%	250/736 = 33.97%
5	ATG → AGG	Met127Arg	3/1774 = 0.17%	1/714 = 0.14%
5	CAT → CGT	His155Arg	1/1774 = 0.06%	0/714 = 0.0%
6	CAA → CGA	Gln192Arg	565/1918 = 29.45%	284/740 = 38.38%
6	CAA → GAA	Gln192Glu	7/1932 = 0.36%	0/740 = 0.0%
7	GCT → GGT	Ala252Gly	1/1894 = 0.05%	0/730 = 0.0%

PON1: Paraoxonase 1

AMD: age-related macular degeneration