Table 4.
Allele and Genotype Frequencies for the Leu55Met PON1 Polymorphism Identified in AMD Patient and Control Populations.
| Controls | Cat 1 | Cat 2 | Cat 3 | Cat 4 | All AMD (Cat 2 – 4) | All AMD (Cat 1 – 4) | |
|---|---|---|---|---|---|---|---|
| N = 368 | N = 117 | N = 175 | N = 105 | N = 522 | N = 802 | N = 919 | |
| Alleles | |||||||
| T | 486 (66.0) | 161 (68.8) | 212 (60.6) | 125 (59.5) | 647 (62.0) | 984 (61.3) | 1145 (62.3) |
| A | 250 (34.0) | 73 (31.2) | 138 (39.4) | 85 (40.5) | 397 (38.0) | 620 (38.7) | 693 (37.7) |
| Significance* | P = 0.474 | P = 0.090 | P = 0.086 | P = 0.080 | P = 0.030 | P = 0.078 | |
| Genotypes | |||||||
| TT | 161 (43.7) | 56 (47.8) | 64 (36.6) | 34 (32.4) | 198 (37.9) | 296 (36.9) | 352 (38.3) |
| TA | 164 (44.6) | 49 (41.9) | 84 (48.0) | 57 (54.3) | 251 (48.1) | 392 (48.9) | 441 (48.0) |
| AA | 43 (11.7) | 12 (10.3) | 27 (15.4) | 14 (13.3) | 73 (14.0) | 114 (14.2) | 126 (13.7) |
| Significance* | P = 0.726 | P = 0.215 | P = 0.111 | P = 0.196 | P = 0.074 | P = 0.179 | |
*
Comparison with control frequencies, Fisher’s Exact (alleles) and χ2 test (genotypes).
Data expressed as the number of subjects (% of entire group).
PON1: Paraoxonase 1
AMD: age-related macular degeneration