Table 2.
Comparisons of demographics, medical history, and APOE genotype between the 1992 and 2001 cohorts: African-American sample, Indianapolis, Indiana
| Variables | 1992 (n = 1,500) | 2001 (n = 1,892) | P value |
|---|---|---|---|
| Mean age (SD) | 77.4 (6.0) | 76.8 (5.6) | .004 |
| Mean years of education (SD) | 9.3 (3.2) | 11.3 (2.7) | <.0001 |
| Female, % | 65.3 | 64.8 | .72 |
| Rural childhood residency, % | 34.2 | 24.8 | <.0001 |
| Ever used alcohol regularly, % | 30.6 | 36.1 | .001 |
| Ever smoked, % | 59.5 | 54.6 | .004 |
| Self or Informant-reported history of: | |||
| Cancer, % | 11.9 | 16.7 | .0001 |
| Parkinson’s disease, % | 1.1 | 1.0 | .61 |
| Heart attack, % | 15.6 | 14.0 | .20 |
| Hypertension, % | 64.7 | 75.2 | <.0001 |
| Diabetes, % | 24.4 | 29.3 | .002 |
| Stroke, % | 12.3 | 15.8 | .003 |
| Head injury, % | 8.7 | 8.9 | .84 |
| Depression, % | 6.9 | 11.1 | <.0001 |
| Medication usage | |||
| Antihypertensive, % | 44.2 | 76.0 | <.0001 |
| Antidiabetic, % | 14.4 | 21.6 | <.0001 |
| Statins, % | 1.6 | 24.1 | <.0001 |
| Genetic testing* | |||
| Has ApoE ε4 allele, % | 39.9 | 36.2 | .16 |
*
Genetic testing was available for 456 subjects in 1992 and 1,133 subjects in 2001.