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. 2011 Jan 20;5:3. doi: 10.3389/fnins.2011.00003

FIGURE 4.

FIGURE 4

Effects of ethanol and its combination with Ro 15-4513 on elevated plus-maze behavior in wildtype γ2F77 and γ2I77 knock-in mice. Male and female γ2I77 and littermate wildtype γ2F77 mice were co-administered with 1 g/kg ethanol (EtOH) and 3 mg/kg Ro15-4513 (or vehicle, Veh) 10 min before being tested for anxiolytic-like behavior on an elevated plus-maze for 5 min. (A) The percent time spent in the open arms of the total testing time. (B) The number of open-arm entries. (C) The percent time spent in the closed arms of the total testing time. (D) The number of closed-arm entries. (E) Total movements. Because three-way ANOVA revealed no sex effect or interaction the data of males and females were pooled. #p < 0.05, ##p < 0.01 compared to vehicle-treated mice within the same genotype (one-way ANOVA followed by Student's t-test). n = 10–19.