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. 2011 Jan 20;5:3. doi: 10.3389/fnins.2011.00003

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Copyright © 2011 Linden, Schmitt, Leppä, Wulff, Wisden, Lüddens and Korpi.

This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Effects of ethanol and its combination with Ro 15-4513 on elevated plus-maze behavior in γ2I77 knock-in mice. Male and female γ2I77 mice were co-administered with 1 g/kg ethanol (EtOH) and 3 mg/kg Ro 15-4513 (or vehicle, Veh) 10 min before being tested on the elevated plus-maze for 5 min. (A) The percent time spent in the open arms of the total testing time (B) The number of open-arm entries. (C) The percent time spent in the closed arms of the total testing time. (D) The number of closed-arm entries. (E) Total movements. Because two-way ANOVA revealed no sex effect or interaction the data of males and females were pooled. ^#p < 0.05, ^##p < 0.01 compared to vehicle-treated mice (one-way ANOVA followed by Student's t-test). n = 24–26.