FIGURE 6.

Effects of ethanol and its combination with Ro 15-4513 on elevated plus-maze behavior in δ+/+ and δ−/− mice. Male and female δ−/− and littermate wildtype δ+/+ mice were co-administered (i.p.) with 1 g/kg ethanol (EtOH) and 3 mg/kg Ro15-4513 (or vehicle, Veh) 10 min before being tested for anxiolytic-like behavior on an elevated plus-maze for 5 min. (A) The percent time spent in the open arms of the total testing time. (B) The number of open-arm entries. (C) The percent time spent in the closed arms of the total testing time. (D) The number of closed-arm entries. (E) Total movements. Because three-way ANOVA revealed no sex effect or interaction the data of males and females were pooled. ^#p < 0.05, ^##p < 0.01 compared to vehicle-treated mice within the same genotype (one-way ANOVA followed by Student's t-test). n = 4–7.